The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges

LI Duo; LI Qiang; ZHANG Rui

doi:10.16152/j.cnki.xdxbzr.2025-05-015

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The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges

更新时间：2025-10-31

- The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges
- Journal of Northwest University (Natural Science Edition) Vol. 55, Issue 5, Pages: 1125-1137(2025)
- 作者机构：
  
  1.西北大学　医学大数据研究中心，陕西　西安　710127
  2.西安石油大学　理学院，陕西　西安　710065
- 作者简介：
- 基金信息：
- DOI：10.16152/j.cnki.xdxbzr.2025-05-015
  CLC： O29;Q189
- Received：01 December 2024，
  
  Published：25 October 2025
- 稿件说明：
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LI Duo, LI Qiang, ZHANG Rui. The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1125-1137.
DOI：

LI Duo, LI Qiang, ZHANG Rui. The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1125-1137. DOI： 10.16152/j.cnki.xdxbzr.2025-05-015.

摘要

癫痫是由大脑神经元超同步异常放电引起的一种神经系统疾病。大量生理实验研究发现，作为维持神经功能活动的一类广泛分布在神经元周围的细胞，神经胶质细胞能够与血管结合构成胶质血管系统向神经元供应能量维持放电活动，然而其能量代谢过程的异常变化与癫痫发作期间大脑神经元异常放电密切相关。基于此，首先针对胶质血管系统能量供应以及神经元放电能量消耗代谢过程，分别对其进行数学刻画并建立能量代谢动力学方程，据此提出一种新的基于能量代谢机制的神经元模型；进而结合数值实验和分岔分析，探索能量代谢异常所诱导的神经元癫痫样放电的动力学转迁过程及其内在机制。实验结果表明，能量产生速率和产生稳态值降低以及能量消耗增强会引起能量供应不足，进而导致神经元放电状态从癫痫发作向扩散性去极化和缺氧扩散性去极化的动力学转迁。

Abstract

Epilepsy is a neurological disease caused by hypersynchronous abnormal discharge of neurons in the brain. Physiological studies have revealed that

as a type of cells widely distributed around neurons to maintain neural functional activities

glial cells can combine with the blood vessels to form the glio-vascular system

whose aberrant alterations in energy metabolism processes are closely related to the abnormal neuronal discharges during epileptic seizures. Based on these findings

the dynamic processes of energy supply in the glio-vascular system and energy consumption in neuronal discharge are firstly mathematically characterized and the dynamics equation of energy metabolism are constructed

thus a novel neuron model based on energy metabolism mechanisms is proposed. Then

combined with numerical experiments and bifurcation analysis

the dynamics transition of neuronal epileptiform discharges caused by abnormal energy metabolism and their underlying mechanisms are explored. The experimental results demonstrate that the reduced rate and steady-state value of energy production and enhanced energy consumption result in insufficient energy supply

which induces the dynamics transition of epileptiform discharges from seizures to spreading depolarization and hypoxic spreading depolarization.

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references

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