Modeling of the neurodynamic mechanisms of acetylcholine regulation of memory storage and recall

QI Lixue; FAN Denggui; SUN Xiaojuan

doi:10.16152/j.cnki.xdxbzr.2025-05-014

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Modeling of the neurodynamic mechanisms of acetylcholine regulation of memory storage and recall

更新时间：2025-10-31

- Modeling of the neurodynamic mechanisms of acetylcholine regulation of memory storage and recall
- Journal of Northwest University (Natural Science Edition) Vol. 55, Issue 5, Pages: 1111-1124(2025)
- 作者机构：
  
  1.北京邮电大学　物理科学与技术学院，北京　100876
  2.北京邮电大学　数学与信息网络教育部重点实验室，北京　100876
  3.北京科技大学　数理学院，北京　100083
  4.北京科技大学　河北省脑机智能与数字疗法重点实验室，北京　100083
- 作者简介：
- 基金信息：
- DOI：10.16152/j.cnki.xdxbzr.2025-05-014
  CLC： Q42;N94
- Received：25 December 2024，
  
  Published：25 October 2025
- 稿件说明：
移动端阅览
QI Lixue, FAN Denggui, SUN Xiaojuan. Modeling of the neurodynamic mechanisms of acetylcholine regulation of memory storage and recall[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1111-1124.
DOI：

QI Lixue, FAN Denggui, SUN Xiaojuan. Modeling of the neurodynamic mechanisms of acetylcholine regulation of memory storage and recall[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1111-1124. DOI： 10.16152/j.cnki.xdxbzr.2025-05-014.

摘要

内侧隔核支持的

振荡被认为是学习和记忆的关键机制，但其通过乙酰胆碱（ACh）调控海马CA1区的记忆存储与回忆功能的具体动力学机制尚未被深入揭示。因此，构建了一个高生物仿真度的海马CA1区微电路模型，包含锥体细胞、轴突-轴突型细胞、篮状细胞、双层细胞与定向腔隙分子细胞，均具有丰富的多隔室形态与复杂的突触连接。模型整合了来自内嗅皮层、CA3 Schaffer侧枝和内侧隔核的网络输入。通过分析不同ACh与GABA

的突触连接强度下的

和

振荡的峰值功率、峰值频率及回忆召回质量，详细评估了ACh对海马CA1网络的调控作用。结果表明：适度的ACh与GABA

输入通过精确调控中间神经元的兴奋抑制平衡，增强锥体神经元的

振荡同步化，有利于LTP突触可塑性的形成及回忆效率的提升；相反，过度输入则会导致中间神经元对锥体神经元放电的过度抑制效应，进而破坏

和

振荡的正常同步，最终显著降低海

马CA1区的存储与回忆功能。该研究揭示了ACh在CA1区兴奋抑制动态平衡中的双重调控作用，为理解记忆存储与回忆机制提供了新的建模工具和理论依据。

Abstract

Oscillations supported by the medial septum are considered to be a key mechanism for learning and memory

but the specific kinetic mechanisms by which they modulate the memory storage and recall functions of the hippocampal CA1 region via acetylcholine (ACh) have not been deeply revealed. Therefore

in this study

we constructed a highly biomimetic microcircuit model of the hippocampal CA1 region

including pyramidal cells

axo-axonic cells

basket cells

bistratified cells

and oriens-lacunosum moleculare cells

which are rich in multicompartmental morphology and complex synaptic connections. Meanwhile

the model integrated network inputs from the entorhinal cortex

CA3 Schaffer lateral branches and medial septal nucleus. Further

the present study assessed in detail the modulatory effects of ACh on the hippocampal CA1 network by analyzing the peak power

peak frequency

and recall quality of sum oscillations under different synaptic connectivity strengths of ACh vs GABA

. The results showed that moderate ACh input enhanced the oscillatory synchronization of pyramidal neurons by precisely regulating the excitation-inhibition balance of interneurons

which was conducive to the formation of LTP synaptic plasticity and the enhancement of recall efficiency; on the contrary

excessive input led to the excessive inhibitory effect of interneurons on pyramidal neuron discharge

which then disrupted the normal synchronization of the sum oscillations and ultimately significantly reduced the hippocampal CA1 area's storage and recall functions. In conclusion

this study reveals the dual regulatory role of ACh in the dynamic balance of excitation-inhibition in the CA1 area

which provides a new modeling tool and theoretical basis for understanding the mechanism of memory storage and recall.

关键词

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references

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