能量代谢异常在癫痫样放电动力学转迁中的作用

李朵; 李强; 张瑞

doi:10.16152/j.cnki.xdxbzr.2025-05-015

您当前的位置：

首页 >

文章列表页 >

能量代谢异常在癫痫样放电动力学转迁中的作用

基于神经动力学建模的脑疾病机制与调控研究 | 更新时间：2025-10-31

- 能量代谢异常在癫痫样放电动力学转迁中的作用
- The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges
- 西北大学学报（自然科学版） 2025年55卷第5期页码：1125-1137
- 作者机构：
  
  1.西北大学　医学大数据研究中心，陕西　西安　710127
  2.西安石油大学　理学院，陕西　西安　710065
- 作者简介：
  
  李朵，女，博士生，从事癫痫神经计算建模与动力学分析研究，liduo@stumail.nwu.edu.cn。
  张瑞，女，教授，博士生导师，从事神经计算建模、机器学习理论与算法等研究，rzhang@nwu.edu.cn。
- 基金信息：
  
  国家自然科学基金(12326612;12071369);陕西数理基础科学研究项目(22JSZ008);陕西省自然科学基金青年项目(2023-JC-QN-0028);中国博士后科学基金面上项目(2022M722580)
- DOI：10.16152/j.cnki.xdxbzr.2025-05-015
  中图分类号： O29;Q189
- 收稿：2024-12-01，
  
  纸质出版：2025-10-25
- 稿件说明：
移动端阅览
李朵, 李强, 张瑞. 能量代谢异常在癫痫样放电动力学转迁中的作用[J]. 西北大学学报（自然科学版）, 2025,55(5):1125-1137.

LI Duo, LI Qiang, ZHANG Rui. The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1125-1137.
李朵, 李强, 张瑞. 能量代谢异常在癫痫样放电动力学转迁中的作用[J]. 西北大学学报（自然科学版）, 2025,55(5):1125-1137. DOI： 10.16152/j.cnki.xdxbzr.2025-05-015.

LI Duo, LI Qiang, ZHANG Rui. The role of abnormal energy metabolism in the dynamics transition of epileptiform discharges[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1125-1137. DOI： 10.16152/j.cnki.xdxbzr.2025-05-015.

摘要

癫痫是由大脑神经元超同步异常放电引起的一种神经系统疾病。大量生理实验研究发现，作为维持神经功能活动的一类广泛分布在神经元周围的细胞，神经胶质细胞能够与血管结合构成胶质血管系统向神经元供应能量维持放电活动，然而其能量代谢过程的异常变化与癫痫发作期间大脑神经元异常放电密切相关。基于此，首先针对胶质血管系统能量供应以及神经元放电能量消耗代谢过程，分别对其进行数学刻画并建立能量代谢动力学方程，据此提出一种新的基于能量代谢机制的神经元模型；进而结合数值实验和分岔分析，探索能量代谢异常所诱导的神经元癫痫样放电的动力学转迁过程及其内在机制。实验结果表明，能量产生速率和产生稳态值降低以及能量消耗增强会引起能量供应不足，进而导致神经元放电状态从癫痫发作向扩散性去极化和缺氧扩散性去极化的动力学转迁。

Abstract

Epilepsy is a neurological disease caused by hypersynchronous abnormal discharge of neurons in the brain. Physiological studies have revealed that

as a type of cells widely distributed around neurons to maintain neural functional activities

glial cells can combine with the blood vessels to form the glio-vascular system

whose aberrant alterations in energy metabolism processes are closely related to the abnormal neuronal discharges during epileptic seizures. Based on these findings

the dynamic processes of energy supply in the glio-vascular system and energy consumption in neuronal discharge are firstly mathematically characterized and the dynamics equation of energy metabolism are constructed

thus a novel neuron model based on energy metabolism mechanisms is proposed. Then

combined with numerical experiments and bifurcation analysis

the dynamics transition of neuronal epileptiform discharges caused by abnormal energy metabolism and their underlying mechanisms are explored. The experimental results demonstrate that the reduced rate and steady-state value of energy production and enhanced energy consumption result in insufficient energy supply

which induces the dynamics transition of epileptiform discharges from seizures to spreading depolarization and hypoxic spreading depolarization.

关键词

Keywords

references

DING D , ZHOU D , SANDER J W , et al . Epilepsy in China: Major progress in the past two decades [J ] . The Lancet Neurology , 2021 , 20 ( 4 ): 316 - 326 .

张瑞 , 宋江玲 , 胡文凤 . 癫痫脑电的特征提取方法综述 [J ] . 西北大学学报(自然科学版) , 2016 , 46 ( 6 ): 781 - 788 .

ZHANG R , SONG J L , HU W F . A review of feature extraction method for epileptic EEGs [J ] . Journal of Northwest University (Natural Science Edition) , 2016 , 46 ( 6 ): 781 - 788 .

BALESTRINI S , ARZIMANOGLOU A , BLÜMCKE I , et al . The aetiologies of epilepsy [J ] . Epileptic Disorders , 2021 , 23 ( 1 ): 1 - 16 .

RHO J M , BOISON D . The metabolic basis of epilepsy [J ] . Nature Reviews Neurology , 2022 , 18 ( 6 ): 333 - 347 .

NAMPOOTHIRI S , NOGUEIRAS R , SCHWANINGER M , et al . Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis [J ] . Nature Metabolism , 2022 , 4 ( 7 ): 813 - 825 .

彭俊 , 王如彬 , 王毅泓 . 大脑血液动力学现象中的能量编码 [J ] . 力学学报 , 2019 , 51 ( 4 ): 1202 - 1209 .

PENG J , WANG R B , WANG Y H . Energy coding of hemodynamic phenomena in the brain [J ] . Chinese Journal of Theoretical and Applied Mechanics , 2019 , 51 ( 4 ): 1202 - 1209 .

PATEL D C , TEWARI B P , CHAUNSALI L , et al . Neuron-glia interactions in the pathophysiology of epilepsy [J ] . Nature Reviews Neuroscience , 2019 , 20 ( 5 ): 282 - 297 .

BOISON D , STEINHÄUSER C . Epilepsy and astrocyte energy metabolism [J ] . Glia , 2018 , 66 ( 6 ): 1235 - 1243 .

SOBOLEVA E B , AMAKHIN D V , SINYAK D S , et al . Modulation of seizure-like events by the small conductance and ATP-sensitive potassium ion channels [J ] . Biochemical and Biophysical Research Communications , 2022 , 623 : 74 - 80 .

WENDLING F , BENQUET P , BARTOLOMEI F , et al . Computational models of epileptiform activity [J ] . Journal of Neuroscience Methods , 2016 , 260 : 233 - 251 .

DEPANNEMAECKER D , EZZATI A , WANG H E , et al . From phenomenological to biophysical models of seizures [J ] . Neurobiology of Disease , 2023 , 182 : 106131 .

韩芳 , 樊登贵 , 张丽媛 , 等 . 神经系统疾病与认知动力学(Ⅰ)：癫痫发作的动力学与控制 [J ] . 力学进展 , 2022 , 52 ( 2 ): 339 - 396 .

HAN F , FAN D G , ZHANG L Y , et al . Neurological disease and cognitive dynamics (I): Dynamics and control of epileptic seizures [J ] . Advances in Mechanics , 2022 , 52 ( 2 ): 339 - 396 .

李强 , 潘敏 , 成波 . 模型与数据双驱动的失眠脑电alpha节律研究 [J ] . 西北大学学报(自然科学版) , 2023 , 53 ( 3 ): 359 - 366 .

LI Q , PAN M , CHENG B . Study of alpha rhythm in insomnia by combination clinical data and neural computational model [J ] . Journal of Northwest University (Natural Science Edition) , 2023 , 53 ( 3 ): 359 - 366 .

CRESSMAN J R , ULLAH G , ZIBURKUS J , et al . The influence of sodium and potassium dynamics on excitability, seizures, and the stability of persistent states: I. Single neuron dynamics [J ] . Journal of Computational Neuroscience , 2009 , 26 ( 2 ): 159 - 170 .

JOLIVET R , COGGAN J S , ALLAMAN I , et al . Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble [J ] . PLoS Computational Biology , 2015 , 11 ( 2 ): e1004036 .

CAPO RANGEL G , PREZIOSO J , GERARDO-GIORDA L , et al . Brain energetics plays a key role in the coordination of electrophysiology, metabolism and hemodynamics: Evidence from an integrated computational model [J ] . Journal of Theoretical Biology , 2019 , 478 : 26 - 39 .

YU Y Y , YUAN Z X , LI J J , et al . Dynamic analysis of epileptic seizures caused by energy failure after ischemic stroke [J ] . Chaos, Solitons & Fractals , 2023 , 176 : 114116 .

CHHABRIA K , CHAKRAVARTHY V S . Low-dimensional models of "neuro-glio-vascular unit" for describing neural dynamics under normal and energy-starved conditions [J ] . Frontiers in Neurology , 2016 , 7 : 160623 .

CHING S , PURDON P L , VIJAYAN S , et al . A neurophysiological-metabolic model for burst suppression [J ] . Proceedings of the National Academy of Sciences , 2012 , 109 ( 8 ): 3095 - 3100 .

TOGLIA P , ULLAH G . Mitochondrial dysfunction and role in spreading depolarization and seizure [J ] . Journal of Computational Neuroscience , 2019 , 47 ( 2 ): 91 - 108 .

SONG J L , KIM J A , STRUCK A F , et al . A model of metabolic supply-demand mismatch leading to secondary brain injury [J ] . Journal of Neurophysiology , 2021 , 126 ( 2 ): 653 - 667 .

WEI Y N , ULLAH G , INGRAM J , et al . Oxygen and seizure dynamics: II. Computational modeling [J ] . Journal of Neurophysiology , 2014 , 112 ( 2 ): 213 - 223 .

WEI Y N , ULLAH G , SCHIFF S J . Unification of neuronal spikes, seizures, and spreading depression [J ] . Journal of Neuroscience , 2014 , 34 ( 35 ): 11733 - 11743 .

DEPANNEMAECKER D , IVANOV A , LILLO D , et al . A unified physiological framework of transitions between seizures, sustained ictal activity and depolarization block at the single neuron level [J ] . Journal of Computational Neuroscience , 2022 , 50 ( 1 ): 33 - 49 .

BONVENTO G , BOLAÑOS J P . Astrocyte-neuron metabolic cooperation shapes brain activity [J ] . Cell Metabolism , 2021 , 33 ( 8 ): 1546 - 1564 .

SILVA D B , RODRIGUES A M , SANTOS L E C , et al . Energy metabolism and the transition between epileptiform activities and spreading depression [C ] // XXVI Brazilian Congress on Biomedical Engineering . Singapore : Springer , 2019 : 567 - 571 .

DE PITTÀ M . Neuron-glial interactions [C ] // Encyclopedia of Computational Neuroscience . New York, NY : Springer New York , 2022 : 2412 - 2440 .

FEI Y Q , SHI R T , SONG Z , et al . Metabolic control of epilepsy: A promising therapeutic target for epilepsy [J ] . Frontiers in Neurology , 2020 , 11 : 592514 .

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

低速下异步电机无速度传感器矢量控制研究