皮层耦合系统下阿尔茨海默病的传播及调控分析

张红慧; 张娅; 昝万荣

doi:10.16152/j.cnki.xdxbzr.2025-05-013

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皮层耦合系统下阿尔茨海默病的传播及调控分析

基于神经动力学建模的脑疾病机制与调控研究 | 更新时间：2025-10-31

- 皮层耦合系统下阿尔茨海默病的传播及调控分析
- Analysis of transmission and regulation of Alzheimer's disease in cortex coupled system
- 西北大学学报（自然科学版） 2025年55卷第5期页码：1095-1110
- 作者机构：
  
  1.西北工业大学　数学与统计学院，陕西　西安　710072
  2.工信部复杂系统动力学与控制重点实验室，陕西　西安　710072
  3.西北大学　数学学院，陕西　西安　710127
- 作者简介：
  
  张红慧，女，教授，从事神经动力学、神经疾病网络建模与调控研究，haozhucy@nwpu.edu.cn。
  昝万荣，女，讲师，从事非线性随机动力学及其数值方法研究，wanrongzan@nwu.edu.cn。
- 基金信息：
  
  国家自然科学基金(12372064;12402037)
- DOI：10.16152/j.cnki.xdxbzr.2025-05-013
  中图分类号： O29
- 收稿：2024-12-23，
  
  纸质出版：2025-10-25
- 稿件说明：
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张红慧, 张娅, 昝万荣. 皮层耦合系统下阿尔茨海默病的传播及调控分析[J]. 西北大学学报（自然科学版）, 2025,55(5):1095-1110.

ZHANG Honghui, ZHANG Ya, ZAN Wanrong. Analysis of transmission and regulation of Alzheimer's disease in cortex coupled system[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1095-1110.
张红慧, 张娅, 昝万荣. 皮层耦合系统下阿尔茨海默病的传播及调控分析[J]. 西北大学学报（自然科学版）, 2025,55(5):1095-1110. DOI： 10.16152/j.cnki.xdxbzr.2025-05-013.

ZHANG Honghui, ZHANG Ya, ZAN Wanrong. Analysis of transmission and regulation of Alzheimer's disease in cortex coupled system[J]. Journal of northwest university (natural science edition), 2025, 55(5): 1095-1110. DOI： 10.16152/j.cnki.xdxbzr.2025-05-013.

摘要

兴奋性谷氨酸能系统的异常活跃是阿尔茨海默病（Alzheimer's disease，AD）患者大脑中的普遍现象。这种过度活跃导致兴奋与抑制机制失衡，被认为是神经元退行性病变和认知障碍发生的关键因素。基于经典的Wendling模型，该研究成功地再现了AD临床患者的典型脑电图（electroencephalogram，EEG）特征，包括

节律减慢和

节律活动增强。随着AD病情的恶化，其病理变化会逐渐弥漫至整个皮质层，这与认知能力的逐渐下降密切相关。因此，拓展了一个双室Wendling模型进一步探索健康生理状态与AD病理状态之间的相互作用。随着兴奋性突触后膜电位强度的增加和群体间耦合强度的增强，AD病理节律的传播变得更加容易。在相同的耦合强度下，健康生理状态更容易受到AD病理状态的影响。此外，验证了快速抑制性中间神经元在传递节律方面的独特优势，这与以往的理论研究结果一致。为了有效控制AD的病理扩散，探索了开环和闭环深部脑刺激（deep brain stimulation，DBS）两种控制策略。与开环DBS相比，闭环控制不仅能使异常脑电信号恢复正常，而且能显著降低能量消耗。研究结果为AD的传播和调控机制提供了新的认识，并为相关神经系统疾病的临床治疗提供了新的思路。

Abstract

Abnormal activity of the excitatory glutamatergic system is a common phenomenon in the brains of patients with Alzheimer's disease (AD). This hyperactivity leads to an imbalance between excitation and inhibition mechanisms

which is considered to be a key factor in the occurrence of neuronal degeneration and cognitive impairment. Based on the classical Wendling model

we successfully reproduced the typical electroencephalogram (EEG) characteristics of clinical AD patients

including the slowing of

rhythm and the enhancement of

rhythm activity. With the deterioration of AD

its pathological change

s will diffuse to the entire cortex gradually

which is closely related to the gradual decline of cognitive ability. So

we developed a two-compartment Wendling model to further explore the interaction between health and AD pathological states. As the intensity of excitatory postsynaptic membrane potential and inter-population coupling strength increase

the propagation of pathological rhythms in AD becomes easier. Interestingly

under the same coupling strength

the healthy physiological state is more susceptible to the pathological state of AD. In addition

we tested the unique advantage of fast inhibitory interneurons in transmitting rhythms

which is consistent with the results of previous theoretical studies. In order to effectively control the pathological spread of AD

we explored two control strategies of open-loop and closed-loop deep brain stimulation (DBS). The closed-loop control could not only normalize the abnormal EEG signal

but also significantly reduce the energy consumption compared with open-loop DBS. This study aims to provide new insights into the propagation and regulation mechanism of AD

and hopefully provide new diagnosis and treatment ideas for the clinical treatment of related neurological diseases.

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references

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