面向低功耗的心脏起搏器信号感知自适应算法及集成电路实现

吴春生; 赵云迪; 袁嘉娴; 刘昕怡; 陈雨琪; 李璟曦; 李靖怡

doi:10.16152/j.cnki.xdxbzr.2025-06-003

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面向低功耗的心脏起搏器信号感知自适应算法及集成电路实现

青年编委专刊 | 更新时间：2026-01-02

- 面向低功耗的心脏起搏器信号感知自适应算法及集成电路实现
- Adaptive algorithm and integrated circuit implementation for signal sensing of low-power pacemakers
- 西北大学学报（自然科学版） 2025年55卷第6期页码：1220-1243
- 作者机构：
  
  1.西安交通大学　未来技术学院，陕西　西安　710115
  2.西安交通大学　基础医学院生物物理学系医学工程研究所，陕西　西安　710061
- 作者简介：
  
  [ "吴春生，博士，西安交通大学基础医学院未来技术学院教授，博士生导师，《西北大学学报（自然科学版）》青年编委。担任中国生物医学工程学会生物医学测量分会委员、陕西省医工融合产业技术创新战略联盟专家委员会委员。主要从事生物医学传感与检测技术研究，发表第一或通讯作者SCI论文80余篇。主编/副主编出版学术专著/教材7部。获国家发明专利授权8项、软件著作权7项。曾获教育部自然科学奖二等奖、陕西省自然科学二等奖、陕西高等学校科学技术研究优秀成果一等奖等多项奖励。主持国家重点研发计划课题、国家自然科学基金委与金砖国家科技创新框架计划合作研究项目等10余项科研项目。" ]
  赵云迪，男，硕士研究生，从事生物医学电子技术研究，zhaoyd2001@stu.xjtu.edu.cn。
- 基金信息：
  
  国家重点研发计划(2023YFC2411902);国家自然科学基金(32471433)
- DOI：10.16152/j.cnki.xdxbzr.2025-06-003
  中图分类号： R318.6
- 收稿：2025-10-26，
  
  纸质出版：2025-12-25
- 稿件说明：
移动端阅览
吴春生, 赵云迪, 袁嘉娴, 等. 面向低功耗的心脏起搏器信号感知自适应算法及集成电路实现[J]. 西北大学学报（自然科学版）, 2025,55(6):1220-1243.

WU Chunsheng, ZHAO Yundi, YUAN Jiaxian, et al. Adaptive algorithm and integrated circuit implementation for signal sensing of low-power pacemakers[J]. Journal of Northwest University (Natural Science Edition), 2025, 55(6): 1220-1243.
吴春生, 赵云迪, 袁嘉娴, 等. 面向低功耗的心脏起搏器信号感知自适应算法及集成电路实现[J]. 西北大学学报（自然科学版）, 2025,55(6):1220-1243. DOI： 10.16152/j.cnki.xdxbzr.2025-06-003.

WU Chunsheng, ZHAO Yundi, YUAN Jiaxian, et al. Adaptive algorithm and integrated circuit implementation for signal sensing of low-power pacemakers[J]. Journal of Northwest University (Natural Science Edition), 2025, 55(6): 1220-1243. DOI： 10.16152/j.cnki.xdxbzr.2025-06-003.

摘要

心脏起搏器是现代医学治疗心律失常的关键植入式设备，其感知功能的精准性与可靠性直接决定了治疗的成败。为解决传统固定参数感知范式难以应对心内电信号复杂动态特性、易导致感知不良或过感知等临床风险的问题，对自适应感知技术的演进进行系统综述。深入剖析从经典自适应算法到智能自适应算法的架构、原理与交互逻辑，详细论述支撑这些算法实现的专用集成电路关键技术，包括高精度模拟前端设计、数模混合信号协同及超低功耗优化，以此构建了一套涵盖从模型化设计、硬件在环测试到符合医疗器械规范的临床前验证的全流程系统实现与性能评估体系。系统梳理了自适应感知技术的完整技术链条，明确了算法与硬件协同设计的关键。该体系能够有效提升感知系统在复杂生理与噪声环境下的安全性、特异性与个体适应性，并为技术的临床应用提供严谨的验证方法。自适应感知技术是突破传统起搏器性能瓶颈的核心方向，未来技术将向多模态传感融合、个性化自适应及预测性维护等方向发展。

Abstract

Cardiac pacemakers are key implantable devices in modern medicine for treating arrhythmias. The accuracy and reliability of their sensing function directly determine the success or failure of treatment. To address the issue that traditional fixed-parameter sensing paradigms struggle to cope with the complex dynamic characteristics of intracardiac electrical signals

leading to clinical risks such as under-sensing or oversensing

a systematic review of the evolution of adaptive sensing technology is conducted. The architecture

principles

and interaction logic of adaptive sensing algorithms

from classic to intelligent

are deeply analyzed. Key technologies of application-specific integrated circuits (ASICs) that support the implementation of these algorithms are elaborated

including high-precision analog front-end design

analog-digital mixed signal coordination

and ultra-low power optimization. A comprehensive system implementation and performance evaluation framework is established

covering model-based design

hardware-in-the-loop testing

and preclinical validation in compliance with medical device regulations. A complete technical chain of adaptive sensing technology is systematically reviewed

and the key points of algorithm and hardware co-design are clarified. This system can effectively enhance the safety

specificity

and individual adaptability of the sensing system in complex physiological and noisy environments

and provide rigorous validation methods for clinical application. Adaptive sensing technology is a core direction to break through the performance bottlenecks of traditional pacemakers. Future technologies will develop towards multi-modal sensor fusion

personalized adaptation

and predictive maintenance.

关键词

Keywords

references

VANNESTE A , SINNAEVE P , HUYS I , et al . Patients' needs and preferences for cardiac pacemaker implantation: A qualitative study on disease and medical device characteristics to inform a quantitative preference study [J ] . The Patient-Patient-Centered Outcomes Research , 2025 , 18 ( 6 ): 763 - 772 .

林中园 , 杨亚莉 , 吉亚军 . 一种双腔起搏器心房感知测试的方法 [J ] . 中国心脏起搏与心电生理杂志 , 2023 , 37 ( 3 ): 247 - 248 .

WAKABAYASHI Y , SHODA M , UESAKO H , et al . Atrioventricular synchronous pacing using a transvenous right atrial lead and an atrial mechanical sensing leadless pacemaker [J ] . Heart Rhythm Case Reports , 2025 , 11 ( 7 ): 621 - 625 .

RODÉS-CABAU J , ELLENBOGEN K A , KRAHN A D , et al . Management of conduction disturbances associated with transcatheter aortic valve replacement [J ] . Journal of the American College of Cardiology , 2019 , 74 ( 8 ): 1086 - 1106 .

张楠 , 李景格 . 现代医疗环境中电磁干扰(EMI)对电子医疗设备的危害 [J ] . 现代电生理学杂志 , 2009 , 16 ( 1 ): 33 - 35 .

LENDERS G D , COLLAS V , HERNANDEZ J M , et al . Depth of valve implantation, conduction disturbances and pacemaker implantation with CoreValve and CoreValve Accutrak system for Transcatheter Aortic Valve Implantation, a multi-center study [J ] . International Journal of Cardiology , 2014 , 176 ( 3 ): 771 - 775 .

金鄂 , 王丽辉 , 王静 , 等 . 永久心脏起搏器植入患者规范化随访及其影响 [J ] . 护理学报 , 2017 , 24 ( 13 ): 76 - 78 .

HTIKE T , CHOUDHURY S , BERA D . Paradoxical under-sensing of atrial lead at high sensitivity setting in dual chamber pacemaker during atrial flutter: What is the mechanism? [J ] . Indian Pacing and Electrophysiology Journal , 2024 , 24 ( 6 ): 330 - 333 .

陈肖艺 . 起搏器植入术后24小时动态心电图监测65例的临床研究 [J ] . 实用医学杂志 , 2012 ; 28 ( 17 ): 2985 - 2986 .

王立群 . 双腔起搏器的起搏基础频率行为 [J ] . 临床心电学杂志 , 2024 , 33 ( 3 ): 229 - 231 .

TAKAHASHI M , KUJIRAOKA H , ARAI T , et al . T-wave oversensing after implantation of pacemakers with automatic sensitivity adjustment in patients with atrioventricular block [J ] . Pacing and Clinical Electrophysiology , 2024 , 47 ( 4 ): 561 - 563 .

CALOIAN B , IRIMIE D A , GUSETU G N , et al . Optimizing cardiac rehabilitation by pacemaker reprogramming. Can we immediately improve the exercise capacity? [J ] . Balneo and PRM Research Journal , 2023 , 14 ( 3 ): 577 .

孙瑞龙 . 心脏起搏器进展和评价 [J ] . 引进国外医药技术与设备 , 1998 , 4 ( 1 ): 68 - 76 .

SUN R L . Progression and evaluation of cardiac pacemaker [J ] . Medical Technology Imports , 1998 , 4 ( 1 ): 68 - 76 .

黄煜洲 , 邬小玫 , 方祖祥 . 起搏器频率自适应功能综述 [J ] . 生物医学工程学进展 , 2010 , 31 ( 1 ): 50 - 54 .

HUANG Y Z , WU X M , FANG Z X . The overview of rate-adaptation in Cardiac Pacemakers [J ] . Advances in Biomedical Engineering 2010 , 31 ( 1 ): 50 - 54 .

BARON-ESQUIVIAS G , MORILLO C A , MOYA-MITJANS A , et al . Dual-chamber pacing with closed loop stimulation in recurrent reflex vasovagal syncope [J ] . Journal of the American College of Cardiology , 2017 , 70 ( 14 ): 1720 - 1728 .

孙娴超 , 黄玥 , 王志勇 . 双腔起搏器植入术后房性心律失常的心电图诊断与程控腔内图分析应用 [J/OL ] . 中国心脏起搏与心电生理杂志 , ( 2024-10-25 ) [ 2025-10-15 ] . https://link.cnki.net/urlid/42.1421.R.20241024.1447.004 https://link.cnki.net/urlid/42.1421.R.20241024.1447.004 .

SALEEM O , AHMED D , IQBAL J . Fuzzy-immune adaptive fractional-order LQI control for robust and intelligent heart rate regulation in Cardiac Pacemakers [J ] . Fractal and Fractional , 2025 , 9 ( 7 ): 424 .

郑周玲 , 唐晨姗 . 起搏器植入患者个体化程控参数调整分析 [J ] . 实用心电与临床诊疗 , 2025 , 34 ( 1 ): 107 - 111 .

ZHENG Z L , TANG C S . Analysis of individualized programming parameter adjustments for patients implanted with pacemakers [J ] . Practical Electrocardiogram and Clinical Treatment 2025 , 34 ( 1 ): 107 - 111 .

HACIOGLU E , MUGNAI G , CZAPLA J , et al . Predictors of successful atrial and ventricular auto capture pacemaker algorithm post implantation: Single-centre experience [J ] . Acta Cardiologica , 2016 , 71 ( 5 ): 612 - 615 .

蒋秋月 , 邓国兰 . 美敦力MicraAV无导线起搏器详解 [J ] . 中国心脏起搏与心电生理杂志 , 2025 , 39 ( 3 ): 242 - 251 .

JIANG Q Y , DENG G L . Detailed explanation of the Medtronic Micra AV leadless pacemaker [J ] . Chinese Journal of Cardiac Pacing and Electrophysiology , 2025 , 39 ( 3 ): 242 - 251 .

KAZAWA S , KAZAWA C , SAKAIDA T , et al . Feasibility of a novel atrial mechanical sensing method for leadless atrioventricular synchronous pacing [J ] . Journal of Cardiovascular Electrophysiology , 2024 , 35 ( 6 ): 1115 - 1120 .

BIFFI M , BERTINI M , SAPORITO D , et al . Automatic management of atrial and ventricular stimulation in a contemporary unselected population of pacemaker recipients: The ESSENTIAL Registry [J ] . Europace , 2016 , 18 ( 10 ): 1551 - 1560 .

HIIPPALA A , SERWER G A , CLAUSSON E , et al . Automatic atrial threshold measurement and adjustment in pediatric patients [J ] . Pacing and Clinical Electrophysiology , 2010 , 33 ( 3 ): 309 - 313 .

BROCKES C , RAHN-SCHÖNBECK M , DURU F , et al . Impact of automatic adjustment of stimulation outputs on pacemaker longevity in a new dual-chamber pacing system [J ] . Journal of Interventional Cardiac Electrophysiology , 2003 , 8 ( 1 ): 45 - 48 .

STRIK M , FRONTERA A , ESCHALIER R , et al . Accuracy of the pacemaker-mediated tachycardia algorithm in Boston Scientific devices [J ] . Journal of Electrocardiology , 2016 , 49 ( 4 ): 522 - 529 .

AKOUM N , MCGANN C , VERGARA G , et al . Atrial fibrosis quantified using late gadolinium enhancement MRI is associated with sinus node dysfunction requiring pacemaker implant [J ] . Journal of Cardiovascular Electrophysiology , 2012 , 23 ( 1 ): 44 - 50 .

WELTE N , GANG E S , SWERDLOW C D , et al . Inappropriate disabling of an ICD noise-detection algorithm in pacemaker-dependent patients [J ] . Pacing and Clinical Electrophysiology , 2019 , 42 ( 4 ): 478 - 482 .

LERMAN I , BU Y F , SINGH R , et al . Next generation bioelectronic medicine: Making the case for non-invasive closed-loop autonomic neuromodulation [J ] . Bioelectronic Medicine , 2025 , 11 ( 1 ): 1 .

吴雯倩 , 单虹颖 , 张千遥 , 等 . 基于三轴加速度传感器的频率自适应心脏起搏器运动心率实验数据采集分析 [J ] . 生物医学工程研究 , 2020 , 39 ( 3 ): 226 - 230, 248 .

WU W Q , SHAN H Y , ZHANG Q Y , et al . Acquisition and analysis of experimental data of rate adaptivepacemaker motion-heart rate based on 3-axis accelerometers [J ] . Journal of Biomedical Engineering Research 2020 , 39 ( 3 ): 226 - 230, 248 .

SEROVA M , ANDREEV D , GIVERTS I , et al . A new algorithm for optimization of rate-adaptive pacing improves exercise tolerance in patients with HFpEF [J ] . Pacing and Clinical Electrophysiology , 2020 , 43 ( 2 ): 223 - 233 .

YÜRDEM B , AKSU M F , SAĜBAŞ M . Design of fractional/integer order PID controller using single DVCC and its cardiac pacemaker application [J ] . Circuits, Systems, and Signal Processing , 2024 , 43 ( 12 ): 7423 - 7447 .

廖勇帆 , 邹明明 , 吴一烽 , 等 . 心脏起搏器电磁兼容性问题的分析与优化策略 [J ] . 环境技术 , 2025 , 43 ( 3 ): 44 - 47, 60 .

LIAO Y F , ZOU M M , WU Y F , et al . Analysis and optimization strategies for electromagnetic compatibility issues of Cardiac Pacemakers [J ] . Environmental Testing , 2025 , 43 ( 3 ): 44 - 47, 60 .

ARNAUD A , GALUP-MONTORO C . Fully integrated signal conditioning of an accelerometer for implantable pacemakers [J ] . Analog Integrated Circuits and Signal Processing , 2006 , 49 ( 3 ): 313 - 321 .

CHEN L T , LIU Y M , CHEN Z Z , et al . An investigation on conductive intracardiac communication dynamic channel gain during the cardiac cycle for leadless pacemakers [J ] . IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology , 2023 , 7 ( 1 ): 82 - 89 .

宋建英 , 张爱爱 , 李飞星 , 等 . 基于无线传感器采集数据的起搏器可靠性检测系统设计 [J ] . 微型电脑应用 , 2024 , 40 ( 3 ): 64 - 67 .

SONG J A , ZHANG A A , LI F X , et al . Design of pacemaker reliability detection system based on wirelesssensor data acquisition [J ] . Microcomputer Applications , 2024 , 40 ( 3 ): 64 - 67 .

LU W , DING R R , WU B J , et al . In-body electromagnetic sensor combined with AI-enhanced electrocardiography for pacemaker working status telemonitoring [J ] . Journal of Sensors , 2021 , 2021 : 8444015 .

ZAMANI M , REZAEIYAN Y , SHOAEI O , et al . A 1.55 μW bio-impedance measurement system for implantable cardiac pacemakers in 0.18 μm CMOS [J ] . IEEE Transactions on Biomedical Circuits and Systems , 2018 , 12 ( 1 ): 211 - 221 .

ANEESH K , MANOJ G , SHYLU SAM S . Design approaches of ultra-low power SAR ADC for biomedical systems: A review [J ] . Journal of Circuits, Systems and Computers , 2022 , 31 ( 12 ): 2230009 .

NAGAKUMARARAJ S , BASKAR S . Dynamic energy consumption using multiobjective genetic algorithm based FFT for implantable cardiac pacemakers [J ] . Analog Integrated Circuits and Signal Processing , 2025 , 122 ( 3 ): 40 .

STRIK M , SACRISTAN B , BORDACHAR P , et al . Artificial intelligence for detection of ventricular oversensing: Machine learning approaches for noise detection within nonsustained ventricular tachycardia episodes remotely transmitted by pacemakers and implantable cardioverter-defibrillators [J ] . Heart Rhythm , 2023 , 20 ( 10 ): 1378 - 1384 .

KRAUSE R , VAN BAVEL J J A , WU C X , et al . Robust neuromorphic coupled oscillators for adaptive pacemakers [J ] . Scientific Reports , 2021 , 11 : 18073 .

江锦洲 , 叶继伦 , 陈月明 . 基于低功耗单片机的心脏起搏器设计 [J ] . 中国医疗器械杂志 , 2019 , 43 ( 4 ): 235 - 237, 285 .

JIANG J Z , YE J L , CHEN Y M . Design of cardiac pacemaker based on low power MCU [J ] . Chinese Journal of Medical Instrumentation , 2019 , 43 ( 4 ): 235 - 237, 285 .

XU J T , YU Z H , WANG Y W , et al . High-sensitivity ultra-low-power electrode resistance monitoring circuit for cardiac pacemakers [J ] . Analog Integrated Circuits and Signal Processing , 2021 , 109 ( 2 ): 479 - 485 .

ABIRI P , ABIRI A , PACKARD R R S , et al . Inductively powered wireless pacing via a miniature pacemaker and remote stimulation control system [J ] . Scientific Reports , 2017 , 7 : 6180 .

张文波 . 微型无导线心脏起搏器的临床应用研究进展 [J ] . 临床医药文献电子杂志 , 2018 , 5 ( A4 ): 235 - 236 .

LIM G B . Development of a miniature, bioresorbable, light-activated pacemaker [J ] . Nature Reviews Cardiology , 2025 , 22 ( 6 ): 395 .

RYSER A , REICHLIN T , BURGER J , et al . A rate-responsive duty-cycling protocol for leadless pacemaker synchronization [J ] . Biomedical Engineering Letters , 2024 , 14 ( 6 ): 1397 - 1407 .

AGNES SHINY RACHEL N , RAJAKUMAR G . A robust low-power fsm cordic lms filter design for exponential noise removal in pacemaker [J ] . International Journal of Electronics , 2024 , 111 ( 12 ): 2303 - 2323 .

王伟明 , 李冰 , 李路明 . 有源植入式医疗器械可靠性研究的特点和进展 [J ] . 清华大学学报(自然科学版) , 2023 , 63 ( 5 ): 792 - 801 .

WANG W M , LI B , LI L M . Characteristics and progress on the reliability research of active implantable medical devices [J ] . Journal of Tsinghua University (Science and Technology) , 2023 , 63 ( 5 ): 792 - 801 .

AGHDAM A D , DABANLOO N J , RAHATABAD F N , et al . Design and stability analysis of an adaptive neuro-fuzzy inference system (ANFIS)-based pacemaker controller in MATLAB Simulink [J ] . Journal of Long-Term Effects of Medical Implants , 2024 , 34 ( 4 ): 1 - 13 .

AGHDAM A D , DABANLOO N J , RAHATABAD F N , et al . Interval type 2 adaptive neuro-fuzzy inference system-based artificial pacemaker design and stability analysis [J ] . Journal of Long-Term Effects of Medical Implants , 2024 , 34 ( 1 ): 9 - 19 .

SRIVASTAVA R , PRUSTY C K K , SAHAI N , et al . An FPGA-based design for power efficient low delay rate adaptive pacemaker using accelerometer and heart rate sensor [J ] . Journal of Medical Engineering & Technology , 2022 , 46 ( 1 ): 16 - 24 .

SWIERZY<inline-formula><alternatives><inline-graphic specific-use="print" xlink:href="media/1000-274X-2025-06-1220-E001.jpg" /><inline-graphic specific-use="big" xlink:href="alternativeImage/1000-274X-2025-06-1220-E001.jpg" /><inline-graphic specific-use="small" xlink:href="alternativeImage/1000-274X-2025-06-1220-E001c.jpg" /></alternatives></inline-formula>SKA E , OREZIAK A , GŁÓWCZY<inline-formula><alternatives><inline-graphic specific-use="print" xlink:href="media/1000-274X-2025-06-1220-E002.jpg" /><inline-graphic specific-use="big" xlink:href="alternativeImage/1000-274X-2025-06-1220-E002.jpg" /><inline-graphic specific-use="small" xlink:href="alternativeImage/1000-274X-2025-06-1220-E002c.jpg" /></alternatives></inline-formula>SKA R , et al . Rate-responsive cardiac pacing: Technological solutions and their applications [J ] . Sensors , 2023 , 23 ( 3 ): 1427 .

AI W W , SURESH V , ROOP P S . Development of closed-loop modelling framework for adaptive respiratory pacemakers [J ] . Computers in Biology and Medicine , 2022 , 141 : 105136 .

BIASI N , VULTAGGIO D M , SEGHETTI P , et al . A Matlab platform for pacemaker algorithm assessment based on anatomically detailed closed-loop computer modeling [J ] . Engineering with Computers , 2025 , 41 : 4511 - 4527 .

TANAKA N , HIKAGE T , NOJIMA T . FEM simulations of implantable cardiac pacemaker EMI triggered by HF-band wireless power transfer system [J ] . IEICE Transactions on Electronics , 2016 , E99.C ( 7 ): 809 - 812 .

HEUER J , KRENZ-BAATH R , OBERMAISSER R . Human-heart-model for hardware-in-the-loop testing of pacemakers [J ] . Computers in Biology and Medicine , 2024 , 180 : 108966 .

底彬 , 许向东 . Micra无导线起搏器对比传统起搏器的临床疗效评价 [J ] . 中西医结合心脑血管病杂志 , 2025 , 23 ( 12 ): 1899 - 1903 .

DI B , XU X D . Single-center clinical efficacy evaluation of micra leadless pacemaker compared with traditional pacemakers [J ] . Chinese Journal of Integrative Medicineon Cardio-Cerbrovascular Disease , 2025 , 23 ( 12 ): 1899 - 1903 .

IP J E , RASHTIAN M , EXNER D V , et al . Atrioventricular synchrony delivered by a dual-chamber leadless pacemaker system [J ] . Circulation , 2024 , 150 ( 6 ): 439 - 450 .

CANTILLON D J , GAMBHIR A , BANKER R , et al . Wireless communication between paired leadless pacemakers for dual-chamber synchrony [J ] . Circulation: Arrhythmia and Electrophysiology , 2022 , 15 ( 7 ): 456 - 463 .

吴礼 , 罗瑞增 , 薛子傲 , 等 . 自驱动技术与植入式心脏电子医疗器件 [J ] . 科技导报 , 2022 , 40 ( 12 ): 53 - 65 .

WU L , LUO R Z , XUE Z A , et al . Self-powered technology and implantable cardiac electronic medical devices [J ] . Science and Technology Review , 2022 , 40 ( 12 ): 53 - 65 .

张粲那 , 王福军 , 罗亚雄 . 无导线心脏起搏器临床应用进展 [J ] . 中国医药科学 , 2024 , 14 ( 7 ): 55 - 58 .

ZHANG C N , WANG F J , LUO Y X . Progress in the clinical application of leadless cardiac pacemakers [J ] . China Medicine and Pharmacy , 2024 , 14 ( 7 ): 55 - 58 .

STRIK M , PLOUX S , THIYAGARAJAH A , et al . Hitting the wall: The hidden challenge of 2∶1 block in pacemaker patients [J ] . Pacing and Clinical Electrophysiology , 2025 , 48 ( 9 ): 953 - 958 .

DEY R , DEY N , DHAR R S , et al . Advances in controller design of pacemakers for pacing control: A comprehensive review [J ] . Annual Reviews in Control , 2024 , 57 : 100930 .

张惠 . 个体化运动康复护理对永久性人工心脏起搏器植入术患者康复的影响 [J ] . 中国医刊 , 2019 , 54 ( 9 ): 955 - 958 .

ZHANG H . Effect of individualized exercise rehabilitation nursing on early postoperative bed out of patients with permanent pacemaker implantation [J ] . Chinese Journal of Medicine , 2019 , 54 ( 9 ): 955 - 958 .

PATON M F , GIERULA J , LOWRY J E , et al . Personalised reprogramming to prevent progressive pacemaker-related left ventricular dysfunction: A phase II randomised, controlled clinical trial [J ] . PLoS One , 2021 , 16 ( 12 ): e0259450 .

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